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Engineered nanopatterned substrates for high-sensitive localized surface plasmon resonance: an assay on Bio-Macro-molecules

Abstract

In this paper, we report on novel iso-Y-shaped-nanopillars based photonic crystals (PC) engineered for plasmonic lab-on-a-chip advanced diagnostics. The iso-Y shaped units are selected on the basis of their plasmonic properties, analyzed numerically and experimentally. We show that accurately choosing nanopillars shape, dimensions and their geometrical disposal it is possible to obtain efficient optically-2D structures for bio-molecules detection by high-sensitive Localized Surface Plasmonic Resonance (LSPR). In particular, an assay is realized by using the Bovine Serum Albumin (BSA), a widely recognized model for bio-system studies. BSA was simply deposited on a Self-Assembled Monolayer (SAM) of 4-mercaptobenzoic acid (4-MBA) previously grown-up on the plasmonic substrate. We demonstrate that the geometries considered allow to design LSPR nano-assays working in the visible-NIR region based on both intensity interrogation and the resonance peak shift permitting the sensing of BSA with a limit of detection in the order of pico molarity (LOD = 233 pM).

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Publication details

The article was received on 21 Mar 2017, accepted on 14 Jun 2017 and first published on 14 Jun 2017


Article type: Paper
DOI: 10.1039/C7TB00777A
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Engineered nanopatterned substrates for high-sensitive localized surface plasmon resonance: an assay on Bio-Macro-molecules

    M. Rippa, R. Castagna, V. Tkachenko, J. Zhou and L. Petti, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB00777A

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