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Issue 31, 2017
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Effects of bone substitute architecture and surface properties on cell response, angiogenesis, and structure of new bone

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Abstract

The success of bone substitutes used to repair bone defects such as critical sized defects depends on the architecture of the porous biomaterial. The architectural parameters and surface properties affect cell seeding efficiency, cell response, angiogenesis, and eventually bone formation. The relevant parameters include pore size and porosity, pore shape and fibre orientation, surface properties, and mechanical properties. For example, small pores are preferable for cell seeding, but limit cell viability, cell proliferation and differentiation. Moreover, the pore size and geometry affect the alignment of cells and the structure of the regenerated bone. This paper presents an overview of the effects of porous biomaterial architecture including pore size and porosity, pore shape and fibre orientation, surface topography and chemistry, and structure stiffness on cell seeding efficiency, cell response, angiogenesis, and bone formation.

Graphical abstract: Effects of bone substitute architecture and surface properties on cell response, angiogenesis, and structure of new bone

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Publication details

The article was received on 17 Mar 2017, accepted on 02 Jun 2017 and first published on 22 Jun 2017


Article type: Review Article
DOI: 10.1039/C7TB00741H
Citation: J. Mater. Chem. B, 2017,5, 6175-6192
  • Open access: Creative Commons BY license
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    Effects of bone substitute architecture and surface properties on cell response, angiogenesis, and structure of new bone

    F. S. L. Bobbert and A. A. Zadpoor, J. Mater. Chem. B, 2017, 5, 6175
    DOI: 10.1039/C7TB00741H

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