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Two-photon photodynamic ablation of tumor cells by mitochondria-targeted iridium(III) complexes in aggregate states

Abstract

By integrating targeting, imaging and treatment, organelle-targeted photodynamic therapy (PDT) has been reported to be an effective strategy for cancer therapy. However, targeting leads to photosensitizers (PSs) accumulating in the targeted organelles, which leads to a reduction in 1O2 generation and fluorescence quenching, especially for the lipophilic mitochondria-targeted PSs. Moreover, because PSs always need exposure to light for a specific period, photobleaching is difficult to avoid. To address these issues, two iridium(III) complexes with aggregation-induced two-photon emission (AITPE) characteristics were developed. With lipophilicity, the complexes aggregated in water and targeted mitochondria. Possessing impressive 1O2 production quantum yields and excellent two-photon properties in the aggregate states, the complexes were successfully used for mitochondria-targeted two-photon PDT in monolayer cells and multicellular spheroids. Our results highlighted that using a PS with aggregation enhanced 1O2 generation, and fluorescence is an effective solution for aggregation in organelle-targeted PDT.

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Publication details

The article was received on 16 Mar 2017, accepted on 15 Jun 2017 and first published on 15 Jun 2017


Article type: Paper
DOI: 10.1039/C7TB00731K
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Two-photon photodynamic ablation of tumor cells by mitochondria-targeted iridium(III) complexes in aggregate states

    H. Chao, K. Qiu, M. Ouyang, Y. Liu, H. Huang, C. Liu, Y. Chen and L. Ji, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB00731K

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