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Issue 22, 2017
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A glutathione-activatable photodynamic and fluorescent imaging monochromatic photosensitizer

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Abstract

The currently available photodynamic sensitizers usually lead to undesirable side effects, including dark toxicity from heavy-atom effect and nonspecific phototoxicity. To address these issues, we designed and prepared a smart photosensitizer from boron dipyrromethene (BODIPY), and the dark toxicity and phototoxicity were reduced via heavy-atom-free substitution and controllable photosensitization, respectively. Importantly, the photodynamic effect together with fluorescence imaging can be simultaneously switched on through the suppression of intramolecular charge transfer (ICT) and photoinduced electron-transfer (PeT) induced by cancer-related biothiol glutathione (GSH) in a buffer solution. Moreover, the sensitizer exhibits obvious fluorescence enhancement and selective phototoxicity towards cancer cells in a biological system upon irradiation. The present monochromatic photosensitizer, which combines fluorescence imaging and targeted PDT treatment within a single chromophore, possesses great potentials as a new activatable theranostic reagent in cancer therapy.

Graphical abstract: A glutathione-activatable photodynamic and fluorescent imaging monochromatic photosensitizer

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Publication details

The article was received on 16 Mar 2017, accepted on 08 May 2017 and first published on 08 May 2017


Article type: Paper
DOI: 10.1039/C7TB00724H
Citation: J. Mater. Chem. B, 2017,5, 4239-4245
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    A glutathione-activatable photodynamic and fluorescent imaging monochromatic photosensitizer

    Z. Li, Y. Liu, L. Chen, X. Hu and Z. Xie, J. Mater. Chem. B, 2017, 5, 4239
    DOI: 10.1039/C7TB00724H

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