Jump to main content
Jump to site search


A glutathione-activatable photodynamic and fluorescent imaging monochromatic photosensitizer

Author affiliations

Abstract

The currently available photodynamic sensitizers usually lead to undesirable side effects, including dark toxicity from heavy-atom effect and nonspecific phototoxicity. To address these issues, we designed and prepared a smart photosensitizer from boron dipyrromethene (BODIPY), and the dark toxicity and phototoxicity were reduced via heavy-atom-free substitution and controllable photosensitization, respectively. Importantly, the photodynamic effect together with fluorescence imaging can be simultaneously switched on through the suppression of intramolecular charge transfer (ICT) and photoinduced electron-transfer (PeT) induced by cancer-related biothiol glutathione (GSH) in a buffer solution. Moreover, the sensitizer exhibits obvious fluorescence enhancement and selective phototoxicity towards cancer cells in a biological system upon irradiation. The present monochromatic photosensitizer, which combines fluorescence imaging and targeted PDT treatment within a single chromophore, possesses great potentials as a new activatable theranostic reagent in cancer therapy.

Graphical abstract: A glutathione-activatable photodynamic and fluorescent imaging monochromatic photosensitizer

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 16 Mar 2017, accepted on 08 May 2017 and first published on 08 May 2017


Article type: Paper
DOI: 10.1039/C7TB00724H
Citation: J. Mater. Chem. B, 2017, Advance Article
  •   Request permissions

    A glutathione-activatable photodynamic and fluorescent imaging monochromatic photosensitizer

    Z. Li, Y. Liu, L. Chen, X. Hu and Z. Xie, J. Mater. Chem. B, 2017, Advance Article , DOI: 10.1039/C7TB00724H

Search articles by author