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Dynamic intracellular tracking nanoparticles via pH-evoked “off–on” fluorescence

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Abstract

Dynamic tracking of nanoparticles in cells faces a big challenge due to fluorescence quenching. Here, the pH-switchable probe spiropyran (SP) was introduced into poly(ethylene glycol) (PEG) via atom transfer radical polymerization (ATRP) to construct expected “off–on” fluorescent nanoparticles. Strong red fluorescence was emitted to efficiently track nanoparticles in cells due to the isomerization of spiropyran to merocyanine in the endosome or lysosome.

Graphical abstract: Dynamic intracellular tracking nanoparticles via pH-evoked “off–on” fluorescence

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Publication details

The article was received on 15 Mar 2017, accepted on 25 Mar 2017 and first published on 04 Apr 2017


Article type: Communication
DOI: 10.1039/C7TB00713B
Citation: J. Mater. Chem. B, 2017, Advance Article
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    Dynamic intracellular tracking nanoparticles via pH-evoked “off–on” fluorescence

    T. Su, F. R. Cheng, J. Cao, J. Q. Yan, X. Y. Peng and B. He, J. Mater. Chem. B, 2017, Advance Article , DOI: 10.1039/C7TB00713B

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