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Issue 24, 2017
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Fusion peptide functionalized hybrid nanoparticles for synergistic drug delivery to reverse cancer drug resistance

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Abstract

A facile self-assembly strategy was developed to decorate polymer/inorganic hybrid nano-sized drug delivery systems with functional peptides. To enhance drug delivery efficacy and overcome tumor drug resistance, a functional fusion peptide containing an RGD sequence for tumor targeting and an R8 sequence for cell penetration was introduced onto the surface of biotinylated carboxymethyl chitosan/CaCO3 (BCMC/CaCO3) hybrid nanoparticles through biotin–avidin interaction to obtain peptide functionalized nanoparticles (PNP). The peptide functionalization results in improved delivery efficiency and effective inhibition for drug resistant tumor cells. Co-delivery of an anti-cancerous drug (doxorubicin hydrochloride, DOX) and a cyclooxygenase-2 inhibitor (celecoxib, CXB) by PNP can further improve the therapeutic efficiency by effectively down-regulating P-gp expression to reduce P-gp mediated drug efflux and increase intracellular drug accumulation.

Graphical abstract: Fusion peptide functionalized hybrid nanoparticles for synergistic drug delivery to reverse cancer drug resistance

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Publication details

The article was received on 09 Mar 2017, accepted on 07 May 2017 and first published on 24 May 2017


Article type: Paper
DOI: 10.1039/C7TB00655A
Citation: J. Mater. Chem. B, 2017,5, 4697-4704
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    Fusion peptide functionalized hybrid nanoparticles for synergistic drug delivery to reverse cancer drug resistance

    J. Wu, X. He, B. Liu, M. Gong, R. Zhuo and S. Cheng, J. Mater. Chem. B, 2017, 5, 4697
    DOI: 10.1039/C7TB00655A

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