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Mineralized Growth of Janus Membrane with Asymmetric Wetting Property for Fast Separation of Trace of Blood

Abstract

The separation of plasma from whole blood is requisite for accurate measurement of glucose levels. From the wettability design point of view, we report in this work the fabrication of a mineralized Janus membrane with asymmetric wetting property, which can transport fast microliter-quantity blood and separate red blood cells out. The membrane is composed of a hydroxyapatite (HAP)-mineralized polyvinylidene fluoride (PVDF) membrane prepared via an interface diffusion-controlled chemical precipitation method. Due to gradient distribution of HAP nanocrystals across PVDF membrane, the composite membrane exhibits asymmetric wetting property where a tiny whole blood droplet (13 µL) can spontaneously permeate across the membrane within 20 s and red blood cells in the whole blood are successfully blocked by the membrane. The membrane is then integrated into blood glucometers for accurate measurements of glucose levels. The results show that the porous membrane can successfully prevent red blood cells in whole blood from entering enzyme layer and the negative effect of hematocrit levels on blood glucose measurements is effectively minimized. An obviously high and stable glucose current signal is achieved.

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Publication details

The article was received on 08 Mar 2017, accepted on 09 May 2017 and first published on 09 May 2017


Article type: Paper
DOI: 10.1039/C7TB00644F
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Mineralized Growth of Janus Membrane with Asymmetric Wetting Property for Fast Separation of Trace of Blood

    J. Jin, W. Zhang, L. Hu, H. Chen, J. S. Gao and X. Zhang, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB00644F

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