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Multifunctional PS@CS@Au–Fe3O4–FA nanocomposites for CT, MR and fluorescence imaging guided targeted-photothermal therapy of cancer cells

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Abstract

In this work, multifunctional polystyrene@chitosan@gold nanoparticles–Fe3O4 nanoparticles–folic acid/indocyanine green (PS@CS@Au–Fe3O4–FA/ICG) nanocomposites that can integrate diagnosis and therapy into one nanoplatform was fabricated. The constructed PS@CS@Au–Fe3O4–FA/ICG nanocomposites possessed excellent computed tomography, magnetic resonance and fluorescence imaging performances which could be used to diagnose tumor and monitor the nanocomposites’ localization in vivo. Moreover, PS@CS@Au–Fe3O4–FA/ICG nanocomposites can be delivered in a targeted manner to cancer cells by folic acid in a receptor-mediated way, and tumor growth could be efficiently inhibited, even completely ablated, under NIR irradiation. That is, the constructed PS@CS@Au–Fe3O4–FA/ICG nanocomposites had great potential for computed tomography, magnetic resonance and fluorescence imaging performances, which could be used to diagnose tumors and to monitor local therapy and fluorescence imaging-guided targeted therapy of cancer cells using nanocomposites.

Graphical abstract: Multifunctional PS@CS@Au–Fe3O4–FA nanocomposites for CT, MR and fluorescence imaging guided targeted-photothermal therapy of cancer cells

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Publication details

The article was received on 08 Mar 2017, accepted on 05 May 2017 and first published on 05 May 2017


Article type: Paper
DOI: 10.1039/C7TB00642J
Citation: J. Mater. Chem. B, 2017, Advance Article
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    Multifunctional PS@CS@Au–Fe3O4–FA nanocomposites for CT, MR and fluorescence imaging guided targeted-photothermal therapy of cancer cells

    Y. Wang, X. Liu, G. Deng, Q. Wang, L. Zhang, Q. Wang and J. Lu, J. Mater. Chem. B, 2017, Advance Article , DOI: 10.1039/C7TB00642J

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