Jump to main content
Jump to site search

Issue 22, 2017
Previous Article Next Article

A silica supported tricarbocyanine based pH nanosensor with a large Stokes shift and a near infrared fluorescence response: performance in vitro and in live cells

Author affiliations

Abstract

We report the synthesis of a near-infrared (NIR) fluorescent pH probe with a remarkable Stokes shift (∼135 nm) based on a tricarbocyanine (Cy-PIP). The fluorescent molecule was anchored to SiO2 nanoparticles (Cy-PIP@SiO2) and is capable of monitoring pH changes within the physiological range (pH 6–8). The Cy-PIP@SiO2 nanoparticles were successfully internalized by HeLa cells as shown by fluorescence confocal microscopy, while flow cytometry revealed pH fluctuations during the endocytic pathway.

Graphical abstract: A silica supported tricarbocyanine based pH nanosensor with a large Stokes shift and a near infrared fluorescence response: performance in vitro and in live cells

Back to tab navigation

Supplementary files

Publication details

The article was received on 06 Mar 2017, accepted on 16 May 2017 and first published on 16 May 2017


Article type: Communication
DOI: 10.1039/C7TB00622E
Citation: J. Mater. Chem. B, 2017,5, 4031-4034
  •   Request permissions

    A silica supported tricarbocyanine based pH nanosensor with a large Stokes shift and a near infrared fluorescence response: performance in vitro and in live cells

    Y. Toum Terrones, F. Coluccio Leskow, A. V. Bordoni, S. L. Acebedo, C. C. Spagnuolo and A. Wolosiuk, J. Mater. Chem. B, 2017, 5, 4031
    DOI: 10.1039/C7TB00622E

Search articles by author

Spotlight

Advertisements