Jump to main content
Jump to site search


Silica supported tricarbocyanine based pH nanosensor with large Stokes shift and near infrared fluorescent response: performance in vitro and live cells

Abstract

We report the synthesis of a near-infrared (NIR) fluorescent pH probe with a remarkable Stokes shift reported ( 135 nm) based on a tricarbocyanine (Cy-PIP). The fluorescent molecule was anchored to SiO2 nanoparticles (Cy-PIP@SiO2) and is capable of monitoring pH changes within the physiological range (pH 6-8). The Cy-PIP@SiO2 nanoparticles were succesfully internalized by HeLa cells as shown by fluorescence confocal microscopy, while flow cytometry revealed pH fluctuations during the endocytic pathway.

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 06 Mar 2017, accepted on 16 May 2017 and first published on 16 May 2017


Article type: Communication
DOI: 10.1039/C7TB00622E
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
  •   Request permissions

    Silica supported tricarbocyanine based pH nanosensor with large Stokes shift and near infrared fluorescent response: performance in vitro and live cells

    Y. Toum Terrones, F. Colluccio Leskow, A. V. Bordoni, S. L. Acebedo, C. C. C. Spagnuolo and A. Wolosiuk, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB00622E

Search articles by author