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Issue 24, 2017
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A 19F NMR probe for the detection of β-galactosidase: simple structure with low molecular weight of 274.2, “turn-on” signal without the background, and good performance applicable in cancer cell line

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Abstract

Based on the efficient cleavage reaction of the C–O ether bond triggered by β-gal selectively, FB-βGal, with good water-solubility, low toxicity, high specificity, excellent water-solubility and high biocompatibility, was prepared, which could report the presence of trace β-gal quickly and conveniently by a significant change in the 19F NMR spectra without any background noise. The successful application of FB-βGal for the detection of β-gal in living Escherichia coli, HeLa cells and OVCAR-3 cells quantitatively makes it a promising candidate for practical application in related fields.

Graphical abstract: A 19F NMR probe for the detection of β-galactosidase: simple structure with low molecular weight of 274.2, “turn-on” signal without the background, and good performance applicable in cancer cell line

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Publication details

The article was received on 06 Mar 2017, accepted on 08 May 2017 and first published on 08 May 2017


Article type: Paper
DOI: 10.1039/C7TB00616K
Citation: J. Mater. Chem. B, 2017,5, 4673-4678
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    A 19F NMR probe for the detection of β-galactosidase: simple structure with low molecular weight of 274.2, “turn-on” signal without the background, and good performance applicable in cancer cell line

    J. Hu, Q. Wu, K. Cheng, Y. Xie, C. Li and Z. Li, J. Mater. Chem. B, 2017, 5, 4673
    DOI: 10.1039/C7TB00616K

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