Preparation of Highly Dispersed γ-Fe2O3 and GdPO4 Co-Functionalized Mesoporous Carbon Spheres for Dual-mode MR Imaging and Anti-cancer Drug Carrying
It is of great promising to integrate paramagnetic gadolinium compounds and superparamagnetic iron oxide-based nanoparticles into ordered mesoporous carbon spheres (OMCSs) as a combined platform for T1- and T2-weighted magnetic resonance (MR) imaging and drug carrying. In this work, highly dispersed γ-Fe2O3 and GdPO4 nanoparticles co-functionalized mesoporous carbon spheres have been successfully prepared by using 3d–4f heterometallic cluster of [Fe6Gd6(μ3-O)2(CO3)(O3PPh)6(O2CtBu)18] as the precursor. Our studying reveals that the multi-scale confinement effects play the role for the concurrent generation of Fe and Gd nanoparticles in the carbon matrix. In addition, dual-mode MR imaging and drug carrying properties are evaluated by in-vitro experiments, which shows a satisfactory r1 and r2 relaxivity value of 8.2 and 94.3 mM−1 s−1 respectively, and the doxorubicin hydrochloride (DOX) carrying amount of 132 mg g–1, suggesting the potential as a combined system for diagnostic & therapy agent.