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Preparation of Highly Dispersed γ-Fe2O3 and GdPO4 Co-Functionalized Mesoporous Carbon Spheres for Dual-mode MR Imaging and Anti-cancer Drug Carrying

Abstract

It is of great promising to integrate paramagnetic gadolinium compounds and superparamagnetic iron oxide-based nanoparticles into ordered mesoporous carbon spheres (OMCSs) as a combined platform for T1- and T2-weighted magnetic resonance (MR) imaging and drug carrying. In this work, highly dispersed γ-Fe2O3 and GdPO4 nanoparticles co-functionalized mesoporous carbon spheres have been successfully prepared by using 3d–4f heterometallic cluster of [Fe6Gd6(μ3-O)2(CO3)(O3PPh)6(O2CtBu)18] as the precursor. Our studying reveals that the multi-scale confinement effects play the role for the concurrent generation of Fe and Gd nanoparticles in the carbon matrix. In addition, dual-mode MR imaging and drug carrying properties are evaluated by in-vitro experiments, which shows a satisfactory r1 and r2 relaxivity value of 8.2 and 94.3 mM−1 s−1 respectively, and the doxorubicin hydrochloride (DOX) carrying amount of 132 mg g–1, suggesting the potential as a combined system for diagnostic & therapy agent.

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Publication details

The article was received on 06 Mar 2017, accepted on 17 Apr 2017 and first published on 18 Apr 2017


Article type: Paper
DOI: 10.1039/C7TB00614D
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Preparation of Highly Dispersed γ-Fe2O3 and GdPO4 Co-Functionalized Mesoporous Carbon Spheres for Dual-mode MR Imaging and Anti-cancer Drug Carrying

    Q. Zhang, P. Wang, X. Li, Y. Yang, X. Liu, F. Zhang, Y. Ling and Y. Zhou, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB00614D

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