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Issue 20, 2017
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Preparation of highly dispersed γ-Fe2O3 and GdPO4 co-functionalized mesoporous carbon spheres for dual-mode MR imaging and anti-cancer drug carrying

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Abstract

There is great interest in integration of paramagnetic gadolinium compounds and superparamagnetic iron oxide-based nanoparticles into ordered mesoporous carbon spheres (OMCSs) as a combined platform for T1- and T2-weighted magnetic resonance (MR) imaging and drug carrying. In this work, highly dispersed γ-Fe2O3 and GdPO4 nanoparticle co-functionalized mesoporous carbon spheres were successfully prepared using a 3d–4f heterometallic cluster of [Fe6Gd63-O)2(CO3)(O3PPh)6(O2CtBu)18] as the precursor. The study reveals that multi-scale confinement effects play a role in concurrent generation of Fe and Gd nanoparticles in the carbon matrix. In addition, dual-mode MR imaging and drug carrying properties were evaluated by in vitro experiments, showing satisfactory r1 and r2 relaxivity values of 8.2 and 94.3 mM−1 s−1, respectively, and doxorubicin hydrochloride (DOX) carrying amount of 132 mg g−1, suggesting potential as a combined system for diagnosis and therapy.

Graphical abstract: Preparation of highly dispersed γ-Fe2O3 and GdPO4 co-functionalized mesoporous carbon spheres for dual-mode MR imaging and anti-cancer drug carrying

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Publication details

The article was received on 06 Mar 2017, accepted on 17 Apr 2017 and first published on 18 Apr 2017


Article type: Paper
DOI: 10.1039/C7TB00614D
Citation: J. Mater. Chem. B, 2017,5, 3765-3770
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    Preparation of highly dispersed γ-Fe2O3 and GdPO4 co-functionalized mesoporous carbon spheres for dual-mode MR imaging and anti-cancer drug carrying

    Q. Zhang, P. Wang, X. Li, Y. Yang, X. Liu, F. Zhang, Y. Ling and Y. Zhou, J. Mater. Chem. B, 2017, 5, 3765
    DOI: 10.1039/C7TB00614D

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