Jump to main content
Jump to site search


A Redox-Responsive Strategy Using Mesoporous Silica Nanoparticles for Co-delivery of siRNA and Doxorubicin

Abstract

Co-delivery of gene and drug therapies for cancer treatment remains a major goal of research into nanocarrier. In this study, mesoporous silica nanoparticles (MSNs) were used to co-deliver siRNA and Dox for redox-controlled release. The present nanocarrier (MSNs-SS-siRNA@Dox) have mesoporous silica cores that can be loaded with Dox, meanwhile siRNA connected to the core surface by disulfide and played a gatekeeper role. Disulfide linkages were also utilized to target intracellular GSH, and their cleavage led to the release of Dox and siRNA. Release of siRNA and Dox correlated with GSH concentrations, and rapid release at 10 mM GSH reflected reductive cleavage of intermediate disulfide linkages. Subsequent experiments using an in vitro Dox delivery and release assay indicated that MSNs-SS-siRNA@Dox significantly enhances the accumulation of Dox in cells compared with that after treatment with free Dox. Moreover, MSNs-SS-siRNA@Dox sufficient efficiency knock down target protein expression. More importantly, MSNs-SS-siRNA@Dox displayed great potential for tumor targeting and achieved satisfactory therapeutic effects on the tumor growth inhibition in vivo. In summary, the present nanoparticles may provide an effective strategy for the design and development of controlled release co-delivery of siRNA and drugs for cancer therapy.

Back to tab navigation

Publication details

The article was received on 06 Mar 2017, accepted on 22 Apr 2017 and first published on 28 Apr 2017


Article type: Paper
DOI: 10.1039/C7TB00613F
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
  •   Request permissions

    A Redox-Responsive Strategy Using Mesoporous Silica Nanoparticles for Co-delivery of siRNA and Doxorubicin

    S. Zhao, M. Xu, C. Cao, Q. Yu, Y. Zhou and J. Liu, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB00613F

Search articles by author

Spotlight

Advertisements