Jump to main content
Jump to site search


Poly(L-lactide) melt spun fiber-aligned scaffolds coated with collagen or chitosan for guiding the directional migration of osteoblasts in vitro

Author affiliations

Abstract

Aligned fiber scaffolds can mimic the parallel aligned fibrils in the extracellular matrix (ECM) of bones, and thus regulate many cellular behaviors. The aligned scaffolds are usually prepared by a microplate micropatterned method, freeze casting, evaporation, slip casting, ice-templating, plain weaving, and fiber forming techniques. In this study, the melt spinning technology, which has the advantages of a higher spinning speed, solvent-free processing and readily scalable production, was used to prepare poly(L-lactide) (PLLA) melt spun fibers with an average diameter of 70.3 ± 11.4 μm. The fibers were further bonded by 5% PLLA tetrahydrofuran solution to prepare PLLA spun fiber-aligned scaffolds. Collagen and chitosan molecules were coated onto the fibers/into the scaffolds to obtain multiple biochemical and surface aligned topography cues, respectively. The collagen or chitosan-coated PLLA aligned scaffolds could effectively improve the viability, adhesion, length and migration behaviors of osteoblasts in vitro. In particular, the collagen coated aligned scaffold had the largest cell length and the fastest migration rate, with a preferential direction along the fibers. This type of scaffold provides a versatile substrate to control cell behaviors, having great potential for bone regeneration.

Graphical abstract: Poly(l-lactide) melt spun fiber-aligned scaffolds coated with collagen or chitosan for guiding the directional migration of osteoblasts in vitro

Back to tab navigation

Publication details

The article was received on 04 Mar 2017, accepted on 26 May 2017 and first published on 26 May 2017


Article type: Paper
DOI: 10.1039/C7TB00601B
Citation: J. Mater. Chem. B, 2017, Advance Article
  •   Request permissions

    Poly(L-lactide) melt spun fiber-aligned scaffolds coated with collagen or chitosan for guiding the directional migration of osteoblasts in vitro

    J. Feng, D. Zhang, M. Zhu and C. Gao, J. Mater. Chem. B, 2017, Advance Article , DOI: 10.1039/C7TB00601B

Search articles by author

Spotlight

Advertisements