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An injectable ionic hydrogel inducing high temperature hyperthermia for microwave tumor ablation

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Abstract

Microwave tumor ablation is of clinical significance and has been considered as a promising cancer minimally invasive therapy. One of the challenges in this field is the optimization of the susceptible agent. Herein, a novel chitosan-based ionic hydrogel which can induce rather high temperature hyperthermia as a susceptible agent for microwave ablation is reported. Owning to the high porosity of the hydrogel, a strong ion confinement effect can be realized, therefore, strong polarization under microwave exposure is ensured for rapid heat generation. In addition, the as-synthesized hydrogel has negligible bio-toxicity and excellent spatial stability in vivo which can guarantee a reproducible therapeutic effect for repeated treatment. In vivo anti-tumor investigation has demonstrated that excellent therapeutic efficiency can be achieved after repeated microwave thermal therapy with a rather low power density (2.0 W, 2.45 GHz). Further, computer simulation was conducted to elucidate the microwave heating mechanism. Our investigation provides a biocompatible and stable agent for microwave tumor ablation and demonstrates its great significance for potential clinical application.

Graphical abstract: An injectable ionic hydrogel inducing high temperature hyperthermia for microwave tumor ablation

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Publication details

The article was received on 27 Feb 2017, accepted on 24 Apr 2017 and first published on 25 Apr 2017


Article type: Paper
DOI: 10.1039/C7TB00556C
Citation: J. Mater. Chem. B, 2017, Advance Article
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    An injectable ionic hydrogel inducing high temperature hyperthermia for microwave tumor ablation

    J. Wang, D. Wang, H. Yan, L. Tao, Y. Wei, Y. Li, X. Wang, W. Zhao, Y. Zhang, L. Zhao and X. Sun, J. Mater. Chem. B, 2017, Advance Article , DOI: 10.1039/C7TB00556C

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