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Simulation of ECM with Silk and Chitosan Nanocomposite Materials

Abstract

Extracellular matrix (ECM) is a system to model with the design of biomaterial matrices for tissue regeneration. Various biomaterial systems have been developed to mimic the composition or microstructure of the ECM. However, emulating multiple facets of the ECM in these systems remains a challenge. Here, we report a new strategy to address this need by using silk fibroin and chitosan nanocomposite materials. Silk fibroin was first assembled into ECM-mimetic nanofibers in water and then blended with chitosan for introducing nanostructural cues. Then the ratios of silk fibroin and chitosan were optimized to imitate protein and glycosaminoglycan compositions. These biomaterial scaffolds had suitable compositions, hierarchical nano-to-micro structures, and appropriate mechanical properties to promote cell proliferation in vitro, and vascularization and tissue regeneration in vivo. Compared to previous silk-based scaffolds, these scaffolds achieved improvements in biocompatibility, suggesting promising applications in tissue regeneration.

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Publication details

The article was received on 18 Feb 2017, accepted on 16 May 2017 and first published on 16 May 2017


Article type: Paper
DOI: 10.1039/C7TB00486A
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Simulation of ECM with Silk and Chitosan Nanocomposite Materials

    Z. Ding, J. Ma, W. He, Z. Ge, Q. Lu and D. Kaplan, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB00486A

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