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Issue 22, 2017
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A highly efficient, low-toxic, wide-spectrum antibacterial coating designed for 3D printed implants with tailorable release properties

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Abstract

Herein, a highly customized and broad-spectrum antibacterial implant was prepared through the combination of 3D printing technology and surface nano-modification. The antibacterial coating, which consists of the film-forming agent polyvinyl alcohol (PVA), polyethylene acid (PAA), and green-synthesized silver nanoparticles (Ag-NPs), was modified on the surface of a 3D-printed implant. The small-sized Ag-NPs (<10 nm) showed potent broad spectrum activity and good biocompatibility in relatively low concentration. Moreover, through changing the content of the Ag-NPs and the proportion of PVA and PAA, the loadings and release rate of Ag-NPs could be controlled according to actual requirements, achieving the goal of precise treatment. Animal experiments demonstrated that the implant system exhibited superior anti-infection performance, which could effectively reduce the postoperative infection risk of implant materials, consequently promoting the practical process of 3D printed implants.

Graphical abstract: A highly efficient, low-toxic, wide-spectrum antibacterial coating designed for 3D printed implants with tailorable release properties

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Publication details

The article was received on 17 Feb 2017, accepted on 14 Apr 2017 and first published on 21 Apr 2017


Article type: Paper
DOI: 10.1039/C7TB00478H
Citation: J. Mater. Chem. B, 2017,5, 4128-4136
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    A highly efficient, low-toxic, wide-spectrum antibacterial coating designed for 3D printed implants with tailorable release properties

    C. Xue, X. Song, M. Liu, F. Ai, M. Liu, Q. Shang, X. Shi, F. Li, X. He, L. Xie, T. Chen, H. Xin and X. Wang, J. Mater. Chem. B, 2017, 5, 4128
    DOI: 10.1039/C7TB00478H

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