A high-efficient, low toxic and wide-spectrum antibacterial coating designed for 3D printed implants with tailorable releasing properties
Here, highly customized and broad-spectrum antibacterial implant was prepared through the combination of 3D printing technology and surface nano-modification. The antibacterial coverage, which consisted of film-forming agent polyvinyl alcohol (PVA), polyethylene acid (PAA) and green syntheized silver nanoparticles (Ag-NPs), was modified on the surface of 3D printing implant. The small sized Ag-NPs (<10nm) showed potent broad spectrum and well biocompatibility in relative low concentration. What’s more, through changing the content of Ag-NPs and the proportion of PVA and PAA, the loadings and release rate of Ag-NPs could be controlled according to actual requirements, achieving the goal of precise treatment. Animal experiments demonstrated that the implant system exhibited superior anti-infection performance, which could effectively reduce the postoperative infection riskof implant materials, consequently promoting the practical process of 3D printing implant.