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A bio-inspired high strength three-layer nanofibers vascular graft with structural guided cells growth

Abstract

Natural blood vessels of human are of three-layer structures including tunica intima, tunica media, and tunica adventitia. These subtle structures enable health blood vessels outstanding strength, elasticity, compliance as well as excellent haemodynamic and anti-thrombus performance. Fabrication of next generation vascular graft that mimics the structures and functionalities of natural blood vessels is becoming the pursuit of biomaterial and medical scientists. Here we fabricate a bio-inspired nanofibers three-layer vascular graft by electrospinning. The inner PLA/PCL layer is favorable adhesion of human umbilical vein endothelial cells that could accelerate endothelialization. The middle PU/PCL layer provides superior mechanical properties (63.40 MPa, 266.78% in longitudinal direction and 52.34 MPa, 319.72% in lateral direction). The outer PLA/PCL layer with circumferential aligned fibers is beneficial for guiding vascular smooth muscle cells in circumferential oriented direction. The bio-inspired three-layer vascular graft with strong mechanical properties and good cell biocompatibility will play an important role in vessel remodeling and regeneration.

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Publication details

The article was received on 16 Feb 2017, accepted on 03 Apr 2017 and first published on 04 Apr 2017


Article type: Paper
DOI: 10.1039/C7TB00465F
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    A bio-inspired high strength three-layer nanofibers vascular graft with structural guided cells growth

    K. Liu, N. Wang, W. Wang, L. Shi, H. Li, F. Guo, L. Zhang, L. Kong, S. Wang and Y. Zhao, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB00465F

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