Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 15, 2017
Previous Article Next Article

Facile preparation of pH/reduction dual-responsive prodrug nanohydrogels for tumor-specific intracellular triggered release with enhanced anticancer efficiency

Author affiliations

Abstract

A facile approach has been developed to prepare novel biocompatible and biodegradable pH/reduction dual-responsive oxidized alginate-doxorubicin (mPEG-OAL–DOX/Cy) prodrug nanohydrogels for tumor-specific intracellular triggered release of anticancer drug doxorubicin (DOX), by conjugating DOX via acid-labile Schiff base linkage into the alginate nanohydrogels crosslinked with bioreducible disulfide bonds. The uniform prodrug nanohydrogels, which were prepared with the oxidized alginate (OAL) with an oxidation degree of 20.0%, PEGylation degree of 7.5 mol%, and crosslinking degree of 94.0%, showed a favorable DOX content (22.7 ± 0.4%) with an average hydrodynamic diameter of about 170 nm. They released DOX rapidly in lower pH media mimicking the tumor microenvironment with a cumulative DOX release rate of 58.4% within 58 h with a sustained release behavior in long term release resulting from their nanohydrogel–micelle transformation, while the premature leakage under the simulated physiological conditions was only 15.5%. The MTT assay demonstrated that the mPEG-OAL–DOX/Cy prodrug nanohydrogels exhibited enhanced inhibitory efficiency against SKOV3 cells, in comparison with free DOX.

Graphical abstract: Facile preparation of pH/reduction dual-responsive prodrug nanohydrogels for tumor-specific intracellular triggered release with enhanced anticancer efficiency

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 13 Feb 2017, accepted on 20 Mar 2017 and first published on 20 Mar 2017


Article type: Paper
DOI: 10.1039/C7TB00433H
Citation: J. Mater. Chem. B, 2017,5, 2840-2848
  •   Request permissions

    Facile preparation of pH/reduction dual-responsive prodrug nanohydrogels for tumor-specific intracellular triggered release with enhanced anticancer efficiency

    T. Zhou, X. Jia, X. Zhao, J. Li and P. Liu, J. Mater. Chem. B, 2017, 5, 2840
    DOI: 10.1039/C7TB00433H

Search articles by author