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Issue 21, 2017
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A spiropyran–coumarin platform: an environment sensitive photoresponsive drug delivery system for efficient cancer therapy

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Abstract

In spite of inventing several anticancer agents the clinical payoff still remains unsatisfactory because of their severe host toxicity due to their nonspecific biodistribution in the body. To achieve high efficiency in anti-cancer drug delivery, thus, we designed and developed a single component photoresponsive drug delivery system, a fusion of two platforms spiropyran and coumarin, which synchronizes two controlling factors: first, the lower pH of cancer tissue, which acts as an internal control and leads to the ring opening of spiropyran resulting in a distinct colour change and fluorescence activation of coumarin; and second, the release of the anti-tumor drug by the externally controlled light. Highly fluorescent nature and promising biocompatibility make the SP–Cou–Cbl system suitable for cell imaging and in vitro studies.

Graphical abstract: A spiropyran–coumarin platform: an environment sensitive photoresponsive drug delivery system for efficient cancer therapy

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Publication details

The article was received on 08 Feb 2017, accepted on 22 Apr 2017 and first published on 24 Apr 2017


Article type: Paper
DOI: 10.1039/C7TB00379J
Citation: J. Mater. Chem. B, 2017,5, 3940-3944
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    A spiropyran–coumarin platform: an environment sensitive photoresponsive drug delivery system for efficient cancer therapy

    S. Barman, J. Das, S. Biswas, T. K. Maiti and N. D. Pradeep Singh, J. Mater. Chem. B, 2017, 5, 3940
    DOI: 10.1039/C7TB00379J

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