Jump to main content
Jump to site search

Issue 28, 2017
Previous Article Next Article

Novel method for the fabrication of ultrathin, free-standing and porous polymer membranes for retinal tissue engineering

Author affiliations

Abstract

Retinal degeneration causes permanent visual loss and affects millions of people worldwide. Cell transplantation may have the potential for retinal regeneration. However, several problems hinder the successful repair of the retina including cell delivery, integration, and survival. Recent studies have shown that the use of scaffolds can address these obstacles. Synthetic scaffolds are being explored to mimic the functions of Bruch's membrane, an extracellular matrix that acts as a molecular sieve, to maintain the metabolic exchange between the vasculature and outer retina. This work aims at fabricating an ultrathin and porous membrane, which mimics Bruch's membrane, using a novel method. We have developed a fast, easy and single-step method to create a free-standing, porous and ultrathin PCL membrane, through dropcasting of a polymer blend on a liquid interface. The free-standing scaffold with nanometer pores is investigated for human retinal pigment epithelial (RPE) cell response. The results demonstrate that the synthesised membrane can act as a potential prosthetic Bruch's membrane for RPE transplantation.

Graphical abstract: Novel method for the fabrication of ultrathin, free-standing and porous polymer membranes for retinal tissue engineering

Back to tab navigation

Supplementary files

Publication details

The article was received on 08 Feb 2017, accepted on 19 Jun 2017 and first published on 20 Jun 2017


Article type: Paper
DOI: 10.1039/C7TB00376E
Citation: J. Mater. Chem. B, 2017,5, 5616-5622
  •   Request permissions

    Novel method for the fabrication of ultrathin, free-standing and porous polymer membranes for retinal tissue engineering

    E. Y. S. Tan, S. Agarwala, Y. L. Yap, C. S. H. Tan, A. Laude and W. Y. Yeong, J. Mater. Chem. B, 2017, 5, 5616
    DOI: 10.1039/C7TB00376E

Search articles by author

Spotlight

Advertisements