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Oral delivery of curcumin via porous polymeric nanoparticles for effective ulcerative colitis therapy

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Abstract

Oral drug delivery has been considered as a promising strategy for ulcerative colitis (UC) therapy. Here, an emulsion solvent evaporation technique was employed to prepare non-porous curcumin (CUR)-loaded polymeric nanoparticles (NPs) and porous CUR-loaded polymeric NPs in the absence or presence of ammonium bicarbonate. The resultant CUR-loaded NPs (non-porous NPs and porous NPs) had a desirable mean particle size of around 260 nm with a narrow size distribution, a uniform pore size distribution, slightly negatively-charged surface, high encapsulation efficiency and controlled drug release capacity. In vitro experiments indicated that Raw 264.7 macrophages exhibited time-dependent accumulation profiles of NPs during the initial 2 h of co-incubation. Furthermore, we found that porous NPs inhibited the secretion of the main pro-inflammatory cytokines (TNF-α, IL-6 and IL-12) and the production of reactive oxygen species much more efficiently than non-porous NPs. Most importantly, in vivo studies demonstrated that oral administered porous NPs had superior therapeutic efficiency in alleviating UC compared with non-porous NPs. The results collectively suggest that porous polymeric NPs can be exploited as efficient oral drug carriers for UC treatment.

Graphical abstract: Oral delivery of curcumin via porous polymeric nanoparticles for effective ulcerative colitis therapy

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Publication details

The article was received on 01 Feb 2017, accepted on 05 May 2017 and first published on 05 May 2017


Article type: Paper
DOI: 10.1039/C7TB00328E
Citation: J. Mater. Chem. B, 2017, Advance Article
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    Oral delivery of curcumin via porous polymeric nanoparticles for effective ulcerative colitis therapy

    Q. Chen, X. Si, L. Ma, P. Ma, M. Hou, S. Bai, X. Wu, Y. Wan, B. Xiao and D. Merlin, J. Mater. Chem. B, 2017, Advance Article , DOI: 10.1039/C7TB00328E

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