A core–shell metal–organic-framework (MOF)-based smart nanocomposite for efficient NIR/H2O2-responsive photodynamic therapy against hypoxic tumor cells

Hui-Juan Cai; Ting-Ting Shen; Jian Zhang; Chang-Fu Shan; Jian-Guo Jia; Xiang Li; Wei-Sheng Liu; Yu Tang

doi:10.1039/C7TB00314E

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A core–shell metal–organic-framework (MOF)-based smart nanocomposite for efficient NIR/H₂O₂-responsive photodynamic therapy against hypoxic tumor cells†

Hui-Juan Cai,^a Ting-Ting Shen,^a Jian Zhang,^b Chang-Fu Shan,^a Jian-Guo Jia,^a Xiang Li,^a Wei-Sheng Liu^a and Yu Tang

*^a

Author affiliations

* Corresponding authors

^a State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China
E-mail: tangyu@lzu.edu.cn

^b Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588-0304, USA

Abstract

Core–shell MOF-based smart nanocomposite UCNPs/MB@ZIF-8@catalase (UCNPs = upconversion nanoparticles; MB = methylene blue; ZIF = zeolitic imidazolate framework) has been constructed for bio-imaging and efficient NIR/H₂O₂-responsive photodynamic therapy against hypoxic tumor cells. The nanoporous MOF shell can prevent aggregation of photosensitizers and serve as an efficient self-sufficient oxygen gas acceptor.

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Article information

DOI: https://doi.org/10.1039/C7TB00314E
Article type: Communication
Submitted: 30 Jan 2017
Accepted: 08 Mar 2017
First published: 08 Mar 2017

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J. Mater. Chem. B, 2017,5, 2390-2394

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A core–shell metal–organic-framework (MOF)-based smart nanocomposite for efficient NIR/H₂O₂-responsive photodynamic therapy against hypoxic tumor cells

H. Cai, T. Shen, J. Zhang, C. Shan, J. Jia, X. Li, W. Liu and Y. Tang, J. Mater. Chem. B, 2017, 5, 2390 DOI: 10.1039/C7TB00314E

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Journal of Materials Chemistry B