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Issue 13, 2017
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A core–shell metal–organic-framework (MOF)-based smart nanocomposite for efficient NIR/H2O2-responsive photodynamic therapy against hypoxic tumor cells

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Abstract

Core–shell MOF-based smart nanocomposite UCNPs/MB@ZIF-8@catalase (UCNPs = upconversion nanoparticles; MB = methylene blue; ZIF = zeolitic imidazolate framework) has been constructed for bio-imaging and efficient NIR/H2O2-responsive photodynamic therapy against hypoxic tumor cells. The nanoporous MOF shell can prevent aggregation of photosensitizers and serve as an efficient self-sufficient oxygen gas acceptor.

Graphical abstract: A core–shell metal–organic-framework (MOF)-based smart nanocomposite for efficient NIR/H2O2-responsive photodynamic therapy against hypoxic tumor cells

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Publication details

The article was received on 30 Jan 2017, accepted on 08 Mar 2017 and first published on 08 Mar 2017


Article type: Communication
DOI: 10.1039/C7TB00314E
Citation: J. Mater. Chem. B, 2017,5, 2390-2394
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    A core–shell metal–organic-framework (MOF)-based smart nanocomposite for efficient NIR/H2O2-responsive photodynamic therapy against hypoxic tumor cells

    H. Cai, T. Shen, J. Zhang, C. Shan, J. Jia, X. Li, W. Liu and Y. Tang, J. Mater. Chem. B, 2017, 5, 2390
    DOI: 10.1039/C7TB00314E

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