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Issue 13, 2017
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Targeted CT/MR dual mode imaging of human hepatocellular carcinoma using lactobionic acid-modified polyethyleneimine-entrapped gold nanoparticles

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Abstract

We report the synthesis and characterization of lactobionic acid-modified multifunctional polyethyleneimine-entrapped gold nanoparticles for targeted dual mode computed tomography/magnetic resonance imaging. The nanodevice displays good X-ray attenuation properties, good r1 relaxivity, and hepatocellular carcinoma targeting specificity, and can be used for targeted CT/MR imaging of hepatocellular carcinoma in vitro and in vivo.

Graphical abstract: Targeted CT/MR dual mode imaging of human hepatocellular carcinoma using lactobionic acid-modified polyethyleneimine-entrapped gold nanoparticles

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Publication details

The article was received on 26 Jan 2017, accepted on 06 Mar 2017, published on 08 Mar 2017 and first published online on 08 Mar 2017


Article type: Communication
DOI: 10.1039/C7TB00286F
Citation: J. Mater. Chem. B, 2017,5, 2395-2401
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    Targeted CT/MR dual mode imaging of human hepatocellular carcinoma using lactobionic acid-modified polyethyleneimine-entrapped gold nanoparticles

    D. Li, J. Yang, S. Wen, M. Shen, L. Zheng, G. Zhang and X. Shi, J. Mater. Chem. B, 2017, 5, 2395
    DOI: 10.1039/C7TB00286F

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