Microwave-Responsive Polymeric Core-Shell Microcarriers for High-Efficiency Controlled Drug Release
High-efficiency, targeted drug release systems are of great importance to medical technologies and have drawn significant research attention in the past decades. Although microwave irradiation has been demonstrated as a promising external drug release trigger owing to its advantageous features including noninvasiveness, high thermal efficiency, and ability to penetrate deep into the body; a drug carrier system which can efficiently receive microwave signals and actively control drug release is still needed. Here we designed a first-of-its-kind microwave-sensitive polymeric drug microcarrier based on poly(p-phenylenediamine) (PpPD)/ poly(N-isopropylacrylamide) (PNIPAM) core-shell structured particles for controlled drug release with high efficiency. The PpPD particle core could efficiently absorb microwave irradiation and convert the electromagnetic radiation to thermal energy, thus actively heating up the PNIPAM shell. Meanwhile the PNIPAM shell could store drug molecules and bursting release them when heated, achieving a self-actuating behavior for drug release. The controlled release tests for folic acid and etoposide demonstrated that this core-shell polymeric system serves as a general drug carrier for highly efficient microwave-triggered controlled drug release.