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Issue 17, 2017
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Layered double hydroxide bio-composites toward excellent systematic anticancer therapy

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Abstract

Multi-therapeutic methodologies have attracted considerable attention toward cancer therapy, which can overcome the limitation of a single therapy and achieve an optimized anticancer efficacy. Herein, we prepared a systematic anticancer drug by intercalating zinc phthalocyanines (ZnPc) into a layered double hydroxide (LDH) gallery, followed by loading doxorubicin (DOX) on the surface (denoted as ZnPc-DOX/LDH). ZnPc is accommodated in the interlayer region of the LDH, which results in a largely enhanced photodynamic therapeutic (PDT) efficiency; while the physisorbed DOX affords a chemotherapeutic effect. In vitro tests performed with KB cells indicate a synergistic anticancer performance as well as excellent biocompatibility compared with pristine ZnPc and DOX. This study demonstrates a promising bio-composite for PDT–chemotherapy systematic therapy, which shows potential application in the field of cancer therapy.

Graphical abstract: Layered double hydroxide bio-composites toward excellent systematic anticancer therapy

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Publication details

The article was received on 19 Jan 2017, accepted on 04 Apr 2017 and first published on 04 Apr 2017


Article type: Paper
DOI: 10.1039/C7TB00209B
Citation: J. Mater. Chem. B, 2017,5, 3212-3216
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    Layered double hydroxide bio-composites toward excellent systematic anticancer therapy

    X. Mei, R. Liang, L. Peng, T. Hu and M. Wei, J. Mater. Chem. B, 2017, 5, 3212
    DOI: 10.1039/C7TB00209B

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