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Issue 31, 2017
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Targeted delivery and release of doxorubicin using a pH-responsive and self-assembling copolymer

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Abstract

Developing a smart cancer drug delivery carrier with enhanced cancer-targeting and effective drug release in tumors is critical for efficient cancer chemotherapy. Herein, we designed a pH-responsive copolymer (PEG-ELP[VH4-70]) that entraps DOX into a hydrophobic core and self-assembles into smart DOX-loaded nanoparticles. The DOX-loaded nanoparticles were stabilized by Zn2+ and disrupted as the pH drops from 7.4 to 5.6. An in vitro study demonstrated that the DOX-loaded nanoparticle system exhibited efficient internalization, triggered the release of DOX into the cytoplasm and enabled the inhibition of tumors effectively. When used to deliver chemotherapeutics to a murine cancer model, PEG-ELP[VH4-70]/DOX accomplished a 4.8-fold suppressed effect relative to the free drug after intravenous injection. This simple strategy can promote preeminent stability for targeting hydrophobic drugs to tumor tissues.

Graphical abstract: Targeted delivery and release of doxorubicin using a pH-responsive and self-assembling copolymer

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Publication details

The article was received on 19 Jan 2017, accepted on 02 Jun 2017 and first published on 02 Jun 2017


Article type: Paper
DOI: 10.1039/C7TB00190H
Citation: J. Mater. Chem. B, 2017,5, 6356-6365
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    Targeted delivery and release of doxorubicin using a pH-responsive and self-assembling copolymer

    K. Huang, L. Zhu, Y. Wang, R. Mo and Z. Hua, J. Mater. Chem. B, 2017, 5, 6356
    DOI: 10.1039/C7TB00190H

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