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Targeted delivery and release of Doxorubicin using pH-responsive and self-assembling copolymer

Abstract

Developing a smart cancer drug delivery carrier with enhanced cancer targeting and effective drug release in tumors is critical for efficient cancer chemotherapy. Herein, we designed pH response copolymer (PEG-ELP[VH4-70]) that entrapped DOX into hydrophobic core and self-assemble into smart DOX-loaded nanoparticles. The DOX-loaded nanoparticles were stabilized by Zn2+ and disrupted as the pH drops from 7.4 to 5.6. In vitro study demonstrated that the DOX-loaded nanoparticle system exhibited efficient inte

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Publication details

The article was received on 19 Jan 2017, accepted on 02 Jun 2017 and first published on 02 Jun 2017


Article type: Paper
DOI: 10.1039/C7TB00190H
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Targeted delivery and release of Doxorubicin using pH-responsive and self-assembling copolymer

    K. Huang, L. Zhu, Y. Wang, R. Mo and Z. Hua, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB00190H

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