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Issue 14, 2017
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A NIR fluorescent chemodosimeter for imaging endogenous hydrogen polysulfides via the CSE enzymatic pathway

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Abstract

Sodium polysulfides (Na2Sn, n > 1) as important raw materials in the chemical industry can afford hydrogen polysulfides (H2Sn, n > 1) under physiological conditions. Hydrogen polysulfides are important reactive sulfide species that play crucial roles in biological systems. The simple detection of H2Sn in solution and biosystems becomes very important as a consequence of the foregoing applications. Herein, we report a NIR fluorescent chemodosimeter, Cy-Sn, displaying turn-on fluorescence after reaction with H2Sn, which exhibits good selectivity and sensitivity in solution and biosystems. Moreover, it was applied successfully to monitor endogenous hydrogen polysulfides via the cystathionine γ-lyase (CSE) enzymatic pathway during inflammation and anti-inflammation in living RAW 264.7 cells. Mouse experiments indicated that this chemodosimeter has good potential to be employed in the imaging of living biosystems.

Graphical abstract: A NIR fluorescent chemodosimeter for imaging endogenous hydrogen polysulfides via the CSE enzymatic pathway

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Publication details

The article was received on 10 Jan 2017, accepted on 17 Feb 2017 and first published on 17 Feb 2017


Article type: Paper
DOI: 10.1039/C7TB00098G
Citation: J. Mater. Chem. B, 2017,5, 2574-2579
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    A NIR fluorescent chemodosimeter for imaging endogenous hydrogen polysulfides via the CSE enzymatic pathway

    J. Ma, J. Fan, H. Li, Q. Yao, F. Xu, J. Wang and X. Peng, J. Mater. Chem. B, 2017, 5, 2574
    DOI: 10.1039/C7TB00098G

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