Jump to main content
Jump to site search


Chitosan-PVA monodisperse millimeter-sized spheres prepared by electrospraying reduce the thromboembolic risk in hemorrhage control

Abstract

Uncontrolled hemorrhage is the main cause of death in many situations. Substantial efforts have been focused on developing more efficient hemostatic agents. Meanwhile, the safety is also critical for their application. Chitosan is an attractive natural polymer and has been widely investigated for hemostatic application. This study sought to incorporate poly(vinyl alcohol) (PVA) component and fabricate them into monodisperse millimeter-sized spheres to improve the efficiency and safety. Chitosan-PVA spheres were fabricated by electrospraying and ionotropic gelation. The millimeter-sized spheres were obtained by adjusting the electrospraying parameters, including applied voltage, working distance, feed rate, polymer solution and component content. The morphology, chemical structure and thermo stability of spheres were characterized by variable pressure scanning electron microscopy (VP-SEM), Fourier transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA). These spheres showed narrow size distribution and good biocompatibility. The hemostatic effect was evaluated both in vitro and in vivo by blood coagulation timing experiment and rat liver hemorrhaging model, and Chitosan50-PVA50 spheres showed the best effect. PVA contributed to the high swelling degree of spheres and enhanced hemostatic effect. This sphere also significantly reduced thromboembolus formation in controlling femoral artery bleeding compared with chitosan powder, providing an efficient and safe hemostasis agent.

Back to tab navigation
Please wait while Download options loads

Publication details

The article was received on 04 Jan 2017, accepted on 10 Apr 2017 and first published on 12 Apr 2017


Article type: Paper
DOI: 10.1039/C7TB00032D
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
  •   Request permissions

    Chitosan-PVA monodisperse millimeter-sized spheres prepared by electrospraying reduce the thromboembolic risk in hemorrhage control

    Q. Chen, Y. Liu, T. Wang, J. Wu, X. Zhai, L. Yanqun, W. W. Lu, H. Pan and X. Zhao, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB00032D

Search articles by author