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Laminin-coated nerve guidance conduits based on poly(L-lactide-co-glycolide) fibers and yarns for promoting Schwann cells’ proliferation and migration

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Abstract

To develop an effective nerve guidance conduit with cooperative effects of topological structure and biological cues for promoting Schwann cells’ (SCs) proliferation and migration, a laminin-coated and yarn-encapsulated poly(L-lactide-co-glycolide) (PLGA) nerve guidance conduit (LC-YE-PLGA NGC) was fabricated in this study. The PLGA fiber yarns were fabricated through a double-nozzle electrospinning system and then the PLGA fibrous outer layer was collected using a general electrospinning method. Subsequently, laminin was coated on the yarn-encapsulated PLGA NGC through covalent binding. The results showed satisfactory tensile mechanical strength of the laminin-coated PLGA fibers/yarns and good compressive mechanical support of the LC-YE-PLGA NGC. SCs proliferation was significantly superior (p < 0.05) on the PLGA and laminin-coated PLGA yarns than the PLGA fibers. Furthermore, the LC-YE-PLGA NGC performed much better in SCs migration compared with the NGCs without yarn-encapsulation or laminin-coating, indicating the synergistic effect of the three-dimensional yarn structure (topological structure) and the laminin-coating (biological cues) for SCs proliferation and migration. Therefore, the LC-YE-PLGA NGC demonstrated promising potential in promoting SCs proliferation and inducing SCs migration in nerve tissue engineering.

Graphical abstract: Laminin-coated nerve guidance conduits based on poly(l-lactide-co-glycolide) fibers and yarns for promoting Schwann cells’ proliferation and migration

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Publication details

The article was received on 22 Dec 2016, accepted on 23 Mar 2017 and first published on 23 Mar 2017


Article type: Paper
DOI: 10.1039/C6TB03330J
Citation: J. Mater. Chem. B, 2017, Advance Article
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    Laminin-coated nerve guidance conduits based on poly(L-lactide-co-glycolide) fibers and yarns for promoting Schwann cells’ proliferation and migration

    T. Wu, D. Li, Y. Wang, B. Sun, D. Li, Y. Morsi, H. El-Hamshary, S. S. Al-Deyab and X. Mo, J. Mater. Chem. B, 2017, Advance Article , DOI: 10.1039/C6TB03330J

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