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Issue 22, 2017
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Biocompatible supramolecular dendrimers bearing a gadolinium-substituted polyanionic core for MRI contrast agents

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Abstract

Two cationic dendrons bearing terminal groups of triethylene glycol monomethyl ether in different generations were used to encapsulate a paramagnetic polyoxometalate cluster K13[Gd(β2-SiW11O39)2], in which the Gd3+ ion was sandwiched by the coordination of two lacunary [β2-SiW11O39]8− sub-clusters, through electrostatic interaction. Benefiting from the surface covering of cationic dendrons and ionic complexation, both inorganic polyanionic core and the complexes formed maintained chemical stability in a physiological environment. In addition, the formed charge-neutralized supramolecular complex dendrimers with biocompatible periphery had low cytotoxicity but high relaxivity for in vitro and in vivo magnetic resonance imaging (MRI) in the self-assembled state. Because of the branched structure of organic components on the cluster surface and the disordered packing of complexes in aggregations, a reasonable communication of cluster core with the bulk environment was concluded. Importantly, due to the assembled particle size and molecular weight, the complex dendrimers were a suitable model for liver-specific MRI contrast agents. The results obtained showed that the dendritic supramolecular hybrid complexes represent potential MRI contrast agents in the development of new biomedical materials.

Graphical abstract: Biocompatible supramolecular dendrimers bearing a gadolinium-substituted polyanionic core for MRI contrast agents

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Publication details

The article was received on 16 Dec 2016, accepted on 13 Apr 2017 and first published on 17 Apr 2017


Article type: Paper
DOI: 10.1039/C6TB03263J
Citation: J. Mater. Chem. B, 2017,5, 4035-4043
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    Biocompatible supramolecular dendrimers bearing a gadolinium-substituted polyanionic core for MRI contrast agents

    S. Zhang, Y. Zheng, D. Fu, W. Li, Y. Wu, B. Li and L. Wu, J. Mater. Chem. B, 2017, 5, 4035
    DOI: 10.1039/C6TB03263J

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