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Issue 13, 2017
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A biomaterial approach to cell reprogramming and differentiation

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Abstract

The cell reprogramming of somatic cells into pluripotent states and subsequent differentiation into certain phenotypes has helped progress regenerative medicine research and other medical applications. Recent research has used viral vectors to induce this reprogramming; however, limitations include low efficiency and safety concerns. In this review, we discuss how biomaterial methods offer potential avenues for either increasing viability and downstream applicability of viral methods, or providing a safer alternative. The use of non-viral delivery systems, such as electroporation, micro/nanoparticles, nucleic acids and the modulation of culture substrate topography and stiffness, has generated valuable insights regarding cell reprogramming.

Graphical abstract: A biomaterial approach to cell reprogramming and differentiation

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Publication details

The article was received on 01 Dec 2016, accepted on 20 Feb 2017 and first published on 20 Feb 2017


Article type: Review Article
DOI: 10.1039/C6TB03130G
Citation: J. Mater. Chem. B, 2017,5, 2375-2389
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    A biomaterial approach to cell reprogramming and differentiation

    J. Long, H. Kim, D. Kim, J. B. Lee and D. Kim, J. Mater. Chem. B, 2017, 5, 2375
    DOI: 10.1039/C6TB03130G

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