Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 12, 2017
Previous Article Next Article

Engineering chemical reaction modules via programming the assembly of DNA hairpins

Author affiliations

Abstract

The architect of enzyme-free chemical reaction modules, working as building blocks in implementing complex computing tasks, was achieved by modulating the assembly of DNA hairpins, including non-catalytic and catalytic systems. The performance of heterogeneous outputted sequences, which were programmed on different hairpins for triggering the downstream reaction, was asymmetric in the non-catalytic system, whereas symmetric in the catalytic system. Furthermore, complicated DNA-only chemical modules possessing controllable species of inputs or outputs were constructed based on our strategy. The kinetic studies revealed that the performance of the chemical modules was toehold length correlated; on the basis of which, a DNA concentration monitor was constructed.

Graphical abstract: Engineering chemical reaction modules via programming the assembly of DNA hairpins

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 29 Nov 2016, accepted on 25 Feb 2017 and first published on 27 Feb 2017


Article type: Paper
DOI: 10.1039/C6TB03098J
Citation: J. Mater. Chem. B, 2017,5, 2297-2301
  •   Request permissions

    Engineering chemical reaction modules via programming the assembly of DNA hairpins

    T. Song, X. Wang and H. Liang, J. Mater. Chem. B, 2017, 5, 2297
    DOI: 10.1039/C6TB03098J

Search articles by author