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Issue 15, 2017
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Novel fluorescent organic nanoparticles as a label-free biosensor for dopamine in serum

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Abstract

Novel fluorescent organic nanoparticles (FONs) composed of an arbitrarily selected organic dye (C2) and an amphiphilic triblock copolymer (Pluronic F127) have been designed and constructed. The as-prepared C2-F127 FONs display uniform morphology with a diameter of around 300 nm and strong orange fluorescence with an emission maximum at 561 nm. When C2-F127 FONs are utilized as a fluorescent probe for detecting dopamine, a significant fluorescence quenching can be observed. Such fluorescence quenching is attributed to the formation of polydopamine coated on the surfaces of the FONs, which leads to photo-induced charge transfer between the organic dye molecules and the formed polydopamine. Moreover, C2-F127 FONs are highly selective to dopamine over other biomaterials, such as glucose, uric acid, ascorbic acid, epinephrine and L-DOPA, including in a competitive environment. As C2-F127 FONs demonstrate good dispersion and high stability in biological media, they are further utilized as a label-free biosensor for detecting dopamine in 10% serum, and satisfactory sensitivity and selectivity are achieved.

Graphical abstract: Novel fluorescent organic nanoparticles as a label-free biosensor for dopamine in serum

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Publication details

The article was received on 28 Nov 2016, accepted on 15 Mar 2017 and first published on 16 Mar 2017


Article type: Paper
DOI: 10.1039/C6TB03077G
Citation: J. Mater. Chem. B, 2017,5, 2750-2756
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    Novel fluorescent organic nanoparticles as a label-free biosensor for dopamine in serum

    L. Ding, Z. Qin, C. Xiang and G. Zhou, J. Mater. Chem. B, 2017, 5, 2750
    DOI: 10.1039/C6TB03077G

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