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Mitochondria-targeting time-gated luminescence probe for hypochlorous acid based on a europium complex

Abstract

Bioresponsive luminescence probes based on lanthanide complexes have shown great utilities in a variety of time-gated luminescence bioassays. However, functional lanthanide complexes that can target individual organelles for probing biospecies therein have rarely been investigated. In this work, a unique Eu3+ complex, Mito-NPSTTA-Eu3+, was designed and synthesized as a probe for the time-gated luminescence sensing of HOCl inside mitochondria of living cells. The probe showed fast, highly sensitive and selective luminescence response to HOCl with a wide pH available range (pH 3-10), and highly specific mitochondria-localization performance. Taking advantages of time-gated luminescence bioimaging and excellent properties of the Eu3+ complex, the generation of endogenous HOCl in RAW 264.7 cells and the uptake of exogenous HOCl by zebrafish were successfully imaged, respectively. The results demonstrated the feasibility of Mito-NPSTTA-Eu3+ for the imaging of mitochondrial HOCl, and validated the potential of our strategy for the design of lanthanide complex-based organelle-targeting bioresponsive probes.

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Publication details

The article was received on 17 Nov 2016, accepted on 15 Mar 2017, published on 17 Mar 2017 and first published online on 17 Mar 2017


Article type: Paper
DOI: 10.1039/C6TB02991D
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Mitochondria-targeting time-gated luminescence probe for hypochlorous acid based on a europium complex

    X. Liu, Z. Tang, B. Song, H. Ma and J. Yuan, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C6TB02991D

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