Jump to main content
Jump to site search

Issue 14, 2017
Previous Article Next Article

Synergistically enhanced upconversion luminescence in Li+-doped core–shell-structured ultrasmall nanoprobes for dual-mode deep tissue fluorescence/CT imaging

Author affiliations

Abstract

The development of upconversion luminescence that allows for multimodal imaging in terms of resolution and penetration depth using a single system is attracting increasing interest for use in clinical molecular imaging and diagnostics. In this study, a simple method for inducing high-intensity upconversion luminescence by doping Li+ ions in a core–shell-structured NaLuF4:Yb,Tm system was developed. The synergistic effects of Li+ doping and the shell layer enhanced the luminescence intensity by approximately 210 times. In vitro and in vivo experiments showed that the high-intensity luminescence of nanoparticles exhibited a depth penetration ability for biological tissue. Owing to the heavy atom effect of the Lu3+ ions, the nanoparticles, which had a size of 23 nm, showed good CT imaging performance when compared with a clinical contrast agent, in addition to allowing for deep tissue imaging. The excellent optical and CT imaging properties of the Li+-doped high-luminescence core–shell upconversion nanoparticles suggest that they are highly suited for use in both deep tissue fluorescence imaging and CT imaging for multimodal diagnosis.

Graphical abstract: Synergistically enhanced upconversion luminescence in Li+-doped core–shell-structured ultrasmall nanoprobes for dual-mode deep tissue fluorescence/CT imaging

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 15 Nov 2016, accepted on 09 Mar 2017 and first published on 10 Mar 2017


Article type: Paper
DOI: 10.1039/C6TB02976K
Citation: J. Mater. Chem. B, 2017,5, 2662-2670
  •   Request permissions

    Synergistically enhanced upconversion luminescence in Li+-doped core–shell-structured ultrasmall nanoprobes for dual-mode deep tissue fluorescence/CT imaging

    M. Hu, D. Ma, Y. Cheng, C. Liu, Z. Zhang, Y. Cai, S. Wu and R. Wang, J. Mater. Chem. B, 2017, 5, 2662
    DOI: 10.1039/C6TB02976K

Search articles by author