Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 12, 2017
Previous Article Next Article

Clustering of hydroxyapatite on a super-twisted collagen microfibril under mechanical tension

Author affiliations

Abstract

It is well-known that nucleation and growth of the mineral phase in bone are intimately linked to the interaction between the apatite phase and the collagen matrix at the molecular scale. The exact mechanism of this interaction, however, is not clear due to the challenges involved in experimental characterization at the small size-scale. Herein, we employed molecular dynamics (MD) simulations to investigate the early state of nucleation (i.e. clustering) and growth of apatite clusters on a super-twisted collagen microfibril under mechanical tension in an aqueous solution. The results reveal that mechanical tension (force) facilitates the clustering and growth of the mineral phase on collagen. These results contribute to the understanding of hydroxyapatite (HAP)-collagen interaction and bone biomechanics at the microfibril level.

Graphical abstract: Clustering of hydroxyapatite on a super-twisted collagen microfibril under mechanical tension

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 30 Oct 2016, accepted on 22 Feb 2017 and first published on 22 Feb 2017


Article type: Paper
DOI: 10.1039/C6TB02835G
Citation: J. Mater. Chem. B, 2017,5, 2235-2244
  •   Request permissions

    Clustering of hydroxyapatite on a super-twisted collagen microfibril under mechanical tension

    Z. Zhou, D. Qian and M. Minary-Jolandan, J. Mater. Chem. B, 2017, 5, 2235
    DOI: 10.1039/C6TB02835G

Search articles by author