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Issue 3, 2017
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Neodymium-doped NaHoF4 nanoparticles as near-infrared luminescent/T2-weighted MR dual-modal imaging agents in vivo

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Abstract

The achievement of efficient near-infrared (NIR) luminescence of lanthanide ions in a paramagnetic nanoparticle (NP) host is highly desirable to optimize the performance of multimodal bioprobes. Herein, we present a facile coprecipitation method to prepare highly uniform NaHoF4:Nd3+ nanoplates. Upon NIR excitation at 785 nm, efficient NIR luminescence of Nd3+ can be obtained from the paramagnetic NaHoF4 hosts. More interestingly, due to energy transfer from the excited state of Nd3+ to the adjacent Ho3+, NIR emission at around 1200 nm from Ho3+ ions is also observed. The r2 value of NaHoF4:Nd3+ NPs reaches 143.7 s−1 mM−1 at a high magnetic field of 11.7 T. By modifying with hydrophilic alpha-cyclodextrin, the NaHoF4:Nd3+ NPs were further successfully applied for the NIR luminescent/T2-weighted MR dual-modal in vivo imaging of nude mice, high contrast NIR imaging of the liver and T2-weighted MR imaging of stem cells in the mouse brain using the NaHoF4:Nd3+ NPs as multimodal bioprobes.

Graphical abstract: Neodymium-doped NaHoF4 nanoparticles as near-infrared luminescent/T2-weighted MR dual-modal imaging agents in vivo

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Publication details

The article was received on 04 Aug 2016, accepted on 05 Dec 2016 and first published on 05 Dec 2016


Article type: Paper
DOI: 10.1039/C6TB01961G
Citation: J. Mater. Chem. B, 2017,5, 504-510
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    Neodymium-doped NaHoF4 nanoparticles as near-infrared luminescent/T2-weighted MR dual-modal imaging agents in vivo

    Y. Feng, Q. Xiao, Y. Zhang, F. Li, Y. Li, C. Li, Q. Wang, L. Shi and H. Lin, J. Mater. Chem. B, 2017, 5, 504
    DOI: 10.1039/C6TB01961G

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