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A biocompatible betaine-functionalized polycation for coacervation

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Abstract

The aqueous nature of complex coacervates provides a biologically-relevant context for various therapeutic applications. In this sense, biological applications demand a corresponding level of biocompatibility from the polyelectrolytes that participate in complex coacervation. Continued development with naturally-occurring polyelectrolytes such as heparin and chitosan underscore such aims. Herein, we design a synthetic polycation, in which betaine is conjugated to a biodegradable polyester backbone. Betaine is a naturally-occurring methylated amino acid that is ubiquitously present in human plasma. Inspired by its vast range of benefits – including but not limited to anti-inflammation, anti-cancer, anti-bacterial, anti-oxidant, protein stabilization, and cardiovascular health – we aim to impart additional functionality to a polycation for eventual use in a complex coacervate with heparin. We report on its in vitro and in vivo biocompatibility, in vitro and in vivo effect on angiogenesis, in vitro effect on microbial growth, and ability to form complex coacervates with heparin.

Graphical abstract: A biocompatible betaine-functionalized polycation for coacervation

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Publication details

The article was received on 01 Sep 2017, accepted on 10 Nov 2017 and first published on 10 Nov 2017


Article type: Paper
DOI: 10.1039/C7SM01763D
Citation: Soft Matter, 2018, Advance Article
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    A biocompatible betaine-functionalized polycation for coacervation

    M. P. Hwang, X. Ding, J. Gao, A. P. Acharya, S. R. Little and Y. Wang, Soft Matter, 2018, Advance Article , DOI: 10.1039/C7SM01763D

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