Jump to main content
Jump to site search


Insights into the interfacial structure–function of poly(ethylene glycol)-decorated peptide-stabilised nanoscale emulsions

Author affiliations

Abstract

The interfacial properties of nanoscale materials have profound influence on biodistribution and stability as well as the effectiveness of sophisticated surface-encoded properties such as active targeting to cell surface receptors. Tailorable nanocarrier emulsions (TNEs) are a novel class of oil-in-water emulsions stabilised by molecularly-engineered biosurfactants that permit single-pot stepwise surface modification with related polypeptides that may be chemically conjugated or genetically fused to biofunctional moieties. We have probed the structure and function of poly(ethylene glycol) (PEG) used to decorate TNEs in this way. The molecular weight of PEG decorating TNEs has considerable impact on the ζ-potential of the emulsion particles, related to differential interfacial thickness of the PEG layer as determined by X-ray reflectometry. By co-modifying TNEs with an antibody fragment, we show that the molecular weight and density of PEG governs the competing parameters of accessibility of the targeting moiety and of shielding the interface from non-specific interactions with the environment. The fundamental understanding of the molecular details of the PEG layer that we present provides valuable insights into the structure–function relationship for soft nanomaterial interfaces. This work therefore paves the way for further rational design of TNEs and other nanocarriers that must interact with their environment in controlled and predictable ways.

Graphical abstract: Insights into the interfacial structure–function of poly(ethylene glycol)-decorated peptide-stabilised nanoscale emulsions

Back to tab navigation

Supplementary files

Publication details

The article was received on 10 Aug 2017, accepted on 10 Oct 2017 and first published on 10 Oct 2017


Article type: Paper
DOI: 10.1039/C7SM01614J
Citation: Soft Matter, 2017, Advance Article
  •   Request permissions

    Insights into the interfacial structure–function of poly(ethylene glycol)-decorated peptide-stabilised nanoscale emulsions

    H. H. Tayeb, S. Piantavigna, C. B. Howard, A. Nouwens, S. M. Mahler, A. P. J. Middelberg, L. He, S. A. Holt and F. Sainsbury, Soft Matter, 2017, Advance Article , DOI: 10.1039/C7SM01614J

Search articles by author

Spotlight

Advertisements