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Issue 37, 2017
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Structural behavior of competitive temperature and pH-responsive tethered polymer layers

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Abstract

Herein, we develop a molecular theory to examine a class of pH and temperature-responsive tethered polymer layers. The response of pH depends on intramolecular charge repulsion of weakly acidic monomers and the response of temperature depends on hydrogen bonding between polymer monomers and water molecules akin to the behavior of water-soluble polymers such as PEG (poly-ethylene glycol) or NIPAAm (n-isopropylacrylamide). We investigate the changes in structural behavior that result for various end-tethered copolymers: pH/T responsive monomers alone, in alternating sequence with hydrophobic monomers, and as 50/50 diblocks with hydrophobic monomers. We find that the sequence and location of hydrophobic units play a critical role in the thermodynamic stability and structural behavior of these responsive polymer layers. Additionally, the polymers exhibit tunable collapse when varying the surface coverage, location and sequence of hydrophobic units as a function of temperature and pH. As far as we know, our results present the first molecularly detailed theory for end-tethered polymers that are both pH and temperature-responsive via hydrogen bonding. We propose that this work holds predictive power for the guided design of future biomaterials.

Graphical abstract: Structural behavior of competitive temperature and pH-responsive tethered polymer layers

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Publication details

The article was received on 01 Aug 2017, accepted on 29 Aug 2017 and first published on 29 Aug 2017


Article type: Paper
DOI: 10.1039/C7SM01538K
Citation: Soft Matter, 2017,13, 6322-6331
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    Structural behavior of competitive temperature and pH-responsive tethered polymer layers

    S. Morochnik, R. J. Nap, G. A. Ameer and I. Szleifer, Soft Matter, 2017, 13, 6322
    DOI: 10.1039/C7SM01538K

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