Jump to main content
Jump to site search

Issue 44, 2017
Previous Article Next Article

N-Cadherin modified lipid bilayers promote neural network formation and circuitry

Author affiliations

Abstract

Neural adhesion, maturation, and the correct wiring of the brain to establish each neuron's intended connectivity are controlled by complex interactions of bioactive molecules such as ligands, growth factors, or enzymes. The correct pairing of adjacent neurons is thought to be highly regulated by ligand-mediated cell–cell adhesion proteins, which are known to induce signaling activities. We developed a new platform consisting of supported lipid bilayers incorporated with Fc-chimera synaptic proteins like ephrinA5 or N-cadherin. We extensively characterized their function employing a quartz crystal microbalance with dissipation (QCM-D), calcium imaging, and immunofluorescence analysis. Our biomimetic platform has been shown to promote neural cell adhesion and to improve neural maturation at day in vitro 7 (DIV7) as indicated by an elevated expression of synaptophysin.

Graphical abstract: N-Cadherin modified lipid bilayers promote neural network formation and circuitry

Back to tab navigation

Supplementary files

Publication details

The article was received on 20 Jun 2017, accepted on 12 Oct 2017 and first published on 13 Oct 2017


Article type: Paper
DOI: 10.1039/C7SM01214D
Citation: Soft Matter, 2017,13, 8096-8107
  •   Request permissions

    N-Cadherin modified lipid bilayers promote neural network formation and circuitry

    K. Zobel, S. E. Choi, R. Minakova, M. Gocyla and A. Offenhäusser, Soft Matter, 2017, 13, 8096
    DOI: 10.1039/C7SM01214D

Search articles by author

Spotlight

Advertisements