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N-cadherin modified lipid bilayer promote neural network formation and circuitry

Abstract

Neural adhesion, maturation and correct wiring of the brain with neurons' intended targets is controlled by complex interactions of bioactive molecules such as ligands, growth factors, or enzymes. The correct pairing of adjacent neurons is thought to be highly regulated by ligand-mediated cell-cell adhesion proteins, which are known to induce signaling activities. We developed a new platform consisting of supported lipid bilayer with incorporated Fc-chimera synaptic proteins like EphrinA5 or N-cadherin. We extensively characterized their function using quartz crystal microbalance with dissipation (QCM-D), calcium imaging and immunofluorescence analysis. Our biomimetic platform has been shown to promote neural cell adhesion and to improve neural maturation at day in vitro 7 (DIV 7) as indicated by an elevated expression of synaptophysin.

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Supplementary files

Publication details

The article was received on 20 Jun 2017, accepted on 12 Oct 2017 and first published on 13 Oct 2017


Article type: Paper
DOI: 10.1039/C7SM01214D
Citation: Soft Matter, 2017, Accepted Manuscript
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    N-cadherin modified lipid bilayer promote neural network formation and circuitry

    K. Zobel, S. Choi, R. Minakova, M. Gocyla and A. Offenhäusser, Soft Matter, 2017, Accepted Manuscript , DOI: 10.1039/C7SM01214D

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