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Time lapse AFM on vesicle formation from mixed lipid bilayers induced by the membrane–active peptide melittin

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Abstract

Melittin is a model system for the action of antimicrobial peptides which are potential candidates for novel antibiotics. We investigated the membrane lysis effect of melittin on phase-separated supported lipid bilayers (DOPC–DPPC) by atomic force microscopy. AFM images show that the peptide first forms defects at the interface between the two lipid phases and then degrades preferentially the liquid-phase DOPC-enriched domains. Vesicular structures of 10–20 nm radius were observed to form, suggesting a mixed carpet–toroidal model mechanism for the resolved action of melittin.

Graphical abstract: Time lapse AFM on vesicle formation from mixed lipid bilayers induced by the membrane–active peptide melittin

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Publication details

The article was received on 02 Jun 2017, accepted on 14 Aug 2017 and first published on 15 Aug 2017


Article type: Paper
DOI: 10.1039/C7SM01095H
Citation: Soft Matter, 2017, Advance Article
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    Time lapse AFM on vesicle formation from mixed lipid bilayers induced by the membrane–active peptide melittin

    M. A. Bodescu, F. Rosenkötter and J. Fritz, Soft Matter, 2017, Advance Article , DOI: 10.1039/C7SM01095H

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