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pH-switchable and Self-healable Hydrogels based on Ketone type Acylhydrazone Dynamic Covalent Bonds

Abstract

Stimuli-responsive hydrogels using dynamic covalent bonds (DCBs) as cross-links may exhibit simultaneously the stimuli-responsibility of the physical gels and stability of the chemical gels. We prepared well-defined, ketone-based polymers based on a commercially available diacetone acrylamide (DAAM) by a reversible addition-fragmentation chain transfer (RAFT) polymerization technique. The polymers could react with hexanedihydrazide yielding hydrogels. The mechanics, the flexible property and gelator concentration of hydrogels can be tuned by varying the ratio of DAAM. Gelation time and hydrogel stability were gravely affected by pH of the surrounding medium. The hydrogels possess self-healing ability without any external stimuli and undergo switchable sol-gel transition by the alternation of pH. In addition, the hydrogels showed pH-responsive controlled release behavior for rhodamine B. This kind of Ketone type acylhydrazone DCBs hydrogels, avoiding aldehyde component, may ameliorate their biocompatibility and find potential applications in biomedicines, tissue engineering, etc.

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Publication details

The article was received on 07 May 2017, accepted on 09 Sep 2017 and first published on 11 Sep 2017


Article type: Paper
DOI: 10.1039/C7SM00916J
Citation: Soft Matter, 2017, Accepted Manuscript
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    pH-switchable and Self-healable Hydrogels based on Ketone type Acylhydrazone Dynamic Covalent Bonds

    Z. Guo, M. Wei, G. Hongjian, Y. Feng, Z. He, Q. Chen, X. Mao, J. L. Zhang and L. Zheng, Soft Matter, 2017, Accepted Manuscript , DOI: 10.1039/C7SM00916J

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