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A model of cell-wall dynamics during sporulation in Bacillus subtilis

Abstract

To survive starvation, Bacillus subtilis forms durable spores. After asymmetric cell division, the septum grows around the forespore in a process called engulfment, but the mechanism of force generation is unknown. Here, we derived a novel biophysical model for the dynamics of cell-wall remodeling during engulfment based on a balancing of dissipative, active, and mechanical forces. By plotting phase diagrams, we predict that sporulation is promoted by a line tension from the attachment of the septum to the outer cell wall, as well as by an imbalance in turgor pressures in the mother cell and forespore compartments. We also predict that significant mother-cell growth hinders engulfment. Hence, relatively simple physical principles may guide this complex biological process.

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Publication details

The article was received on 25 Apr 2017, accepted on 12 Oct 2017 and first published on 13 Oct 2017


Article type: Paper
DOI: 10.1039/C7SM00818J
Citation: Soft Matter, 2017, Accepted Manuscript
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    A model of cell-wall dynamics during sporulation in Bacillus subtilis

    L. Yap and R. Endres, Soft Matter, 2017, Accepted Manuscript , DOI: 10.1039/C7SM00818J

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