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Microviscosity, encapsulation, and permeability of 2-ketooctanoic acid vesicle membranes

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Abstract

In the current work, the microviscosity, encapsulation, and permeability of 2-ketooctanoic acid (KOCOOH) vesicle membranes were investigated by steady-state and time-resolved fluorescence techniques, using 1,6-diphenyl-1,3,5-hexatriene (DPH), riboflavin, and calcein as fluorescence probes. Our results show that the microviscosity of KOCOOH membranes is similar to that of common bilayer aggregates, the KOCOOH vesicles have the ability to encapsulate hydrophilic guests, and the KOCOOH membranes are permeable to ions. The permeation of OH− across KOCOOH membranes can be well described using a first-order kinetic model. The KOCOOH vesicles may be a good alternative protocell model that possesses some functional properties necessary for early cell membranes. To the best of our knowledge, this is the first report on the characteristics of vesicle membranes of single-tailed keto-acid amphiphiles.

Graphical abstract: Microviscosity, encapsulation, and permeability of 2-ketooctanoic acid vesicle membranes

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Publication details

The article was received on 05 Mar 2017, accepted on 11 Apr 2017 and first published on 12 Apr 2017


Article type: Paper
DOI: 10.1039/C7SM00458C
Citation: Soft Matter, 2017, Advance Article
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    Microviscosity, encapsulation, and permeability of 2-ketooctanoic acid vesicle membranes

    H. Xu, N. Du, Y. Song, S. Song and W. Hou, Soft Matter, 2017, Advance Article , DOI: 10.1039/C7SM00458C

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