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Buckling-induced F-actin fragmentation modulates the contraction of active cytoskeletal networks

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Abstract

Actomyosin contractility originating from interactions between F-actin and myosin facilitates various structural reorganizations of the actin cytoskeleton. Cross-linked actomyosin networks show a tendency to contract to single or multiple foci, which has been investigated extensively in numerous studies. Recently, it was suggested that suppression of F-actin buckling via an increase in bending rigidity significantly reduces network contraction. In this study, we demonstrate that networks may show the largest contraction at intermediate bending rigidity, not at the lowest rigidity, if filaments are severed by buckling arising from myosin activity as demonstrated in recent experiments; if filaments are very flexible, frequent severing events can severely deteriorate network connectivity, leading to the formation of multiple small foci and low network contraction. By contrast, if filaments are too stiff, the networks exhibit minimal contraction due to the inhibition of filament buckling. This study reveals that buckling-induced filament severing can modulate the contraction of active cytoskeletal networks, which has been neglected to date.

Graphical abstract: Buckling-induced F-actin fragmentation modulates the contraction of active cytoskeletal networks

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Publication details

The article was received on 02 Dec 2016, accepted on 31 Mar 2017 and first published on 11 Apr 2017


Article type: Paper
DOI: 10.1039/C6SM02703B
Citation: Soft Matter, 2017, Advance Article
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    Buckling-induced F-actin fragmentation modulates the contraction of active cytoskeletal networks

    J. Li, T. Biel, P. Lomada, Q. Yu and T. Kim, Soft Matter, 2017, Advance Article , DOI: 10.1039/C6SM02703B

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