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Cell division and death inhibit glassy behaviour of confluent tissues

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Abstract

We investigate the effects of cell division and apoptosis on collective dynamics in two-dimensional epithelial tissues. Our model includes three key ingredients observed across many epithelia, namely cell–cell adhesion, cell death and a cell division process that depends on the surrounding environment. We show a rich non-equilibrium phase diagram depending on the ratio of cell death to cell division and on the adhesion strength. For large apoptosis rates, cells die out and the tissue disintegrates. As the death rate decreases, however, we show, consecutively, the existence of a gas-like phase, a gel-like phase, and a dense confluent (tissue) phase. Most striking is the observation that the tissue is self-melting through its own internal activity, ruling out the existence of any glassy phase.

Graphical abstract: Cell division and death inhibit glassy behaviour of confluent tissues

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Publication details

The article was received on 15 Nov 2016, accepted on 31 Mar 2017 and first published on 03 Apr 2017


Article type: Paper
DOI: 10.1039/C6SM02580C
Citation: Soft Matter, 2017, Advance Article
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    Cell division and death inhibit glassy behaviour of confluent tissues

    D. A. Matoz-Fernandez, K. Martens, R. Sknepnek, J. L. Barrat and S. Henkes, Soft Matter, 2017, Advance Article , DOI: 10.1039/C6SM02580C

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