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Issue 16, 2017
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NMR probing and visualization of correlated structural fluctuations in intrinsically disordered proteins

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Abstract

A novel statistical analysis of paramagnetic relaxation enhancement (PRE) and paramagnetic relaxation interference (PRI) based nuclear magnetic resonance (NMR) data is proposed based on the computation of correlation matrices. The technique is demonstrated with an example of the intrinsically disordered proteins (IDPs) osteopontin (OPN) and brain acid soluble protein 1 (BASP1). The correlation analysis visualizes in detail the subtleties of conformational averaging in IDPs and highlights the presence of correlated structural fluctuations of individual sub-domains in IDPs.

Graphical abstract: NMR probing and visualization of correlated structural fluctuations in intrinsically disordered proteins

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Publication details

The article was received on 19 Jan 2017, accepted on 27 Mar 2017 and first published on 28 Mar 2017


Article type: Paper
DOI: 10.1039/C7CP00430C
Citation: Phys. Chem. Chem. Phys., 2017,19, 10651-10656
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    NMR probing and visualization of correlated structural fluctuations in intrinsically disordered proteins

    D. Kurzbach, A. Beier, A. Vanas, A. G. Flamm, G. Platzer, T. C. Schwarz and R. Konrat, Phys. Chem. Chem. Phys., 2017, 19, 10651
    DOI: 10.1039/C7CP00430C

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