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A lesson for site-selective C–H functionalization on 2-pyridones: radical, organometallic, directing group and steric controls

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Abstract

A 2-pyridone ring is a frequently occurring subunit in natural products, biologically active compounds, and pharmaceutical targets. Thus, the selective synthesis of substituted 2-pyridone derivatives through decoration and/or formation of pyridone rings has been one of the important longstanding subjects in organic synthetic chemistry. This minireview focuses on recent advances in site-selective C–H functionalization on 2-pyridone. The reported procedures are categorized according to the site selectivity that is achieved, and the substrate scope, limitations, mechanism, and controlling factors are briefly summarized.

Graphical abstract: A lesson for site-selective C–H functionalization on 2-pyridones: radical, organometallic, directing group and steric controls

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Publication details

The article was received on 18 Oct 2017, accepted on 26 Nov 2017 and first published on 27 Nov 2017


Article type: Minireview
DOI: 10.1039/C7SC04509C
Citation: Chem. Sci., 2018, Advance Article
  • Open access: Creative Commons BY-NC license
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    A lesson for site-selective C–H functionalization on 2-pyridones: radical, organometallic, directing group and steric controls

    K. Hirano and M. Miura, Chem. Sci., 2018, Advance Article , DOI: 10.1039/C7SC04509C

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